Dupixent vs Cosentyx
Side-by-side drug price comparison from Medicare Part D data
Verdict
Dupixent costs 22% less per claim than Cosentyx ($2819.00 vs $3616.00). Cosentyx has a generic alternative available. Total Medicare spending: Dupixent at $4.4B vs Cosentyx at $3.1B.
| Metric | Dupixent | Cosentyx |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $2,819* | $3,616 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $4.4B | $3.1B |
| Total Claims | 1,560,000 | 864,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 35.2% | 8.9%* |
| Generic Available | No | Yes |
| Condition | Autoimmune Diseases | Autoimmune Diseases |
| Total Beneficiaries | 245,000 | 120,000 |
Dupixent costs 22% less per claim than Cosentyx ($2819.00 vs $3616.00). Cosentyx has a generic alternative available. Total Medicare spending: Dupixent at $4.4B vs Cosentyx at $3.1B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Dupixent and Cosentyx. What follows is the interpretation — which specific axes carry the most weight for Dupixent versus Cosentyx, and which differences are large enough to influence a real decision.
Practical use of the comparison: read the data above, then drill into the individual Dupixent and Cosentyx detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.