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DrugPrice

All Prescription Drugs — A to Z

Browse every prescription drug in the Medicare Part D database.507 medications totaling $355.8B in annual spending. Updated April 2026.

507
Drugs Tracked
$355.8B
Annual Spending
$221.00
Avg Cost/Claim
95%
Have Generics

Browse by Category

By Condition
41 conditions
By Drug Class
11 therapeutic classes
By Manufacturer
Pharma companies
Most Expensive
Top-cost drugs
Generic Watch
Upcoming generics
By Price Range
4 price tiers
By Dosage Form
Tablet, injection, etc.
By Price Trend
Increases & decreases

Top 20 Drugs by Medicare Spending

#DrugGenericMedicare Spending
1EliquisApixaban$16.6B
2RevlimidLenalidomide$7.8B
3KeytrudaPembrolizumab$7.2B
4HumiraAdalimumab$6.5B
5ImbruvicaIbrutinib$5.7B
6StelaraUstekinumab$5.6B
7OpdivoNivolumab$5.1B
8XareltoRivaroxaban$5.0B
9OzempicSemaglutide$5.0B
10EntrestoSacubitril/Valsartan$4.8B
11IbrancePalbociclib$4.5B
12DupixentDupilumab$4.4B
13TrulicityDulaglutide$4.2B
14XtandiEnzalutamide$4.1B
15JardianceEmpagliflozin$3.9B
16BiktarvyBictegravir/Emtricitabine/TAF$3.8B
17EyleaAflibercept$3.7B
18OcrevusOcrelizumab$3.5B
19TrikaftaElexacaftor/Tezacaftor/Ivacaftor$3.5B
20PomalystPomalidomide$3.3B

10 Most Expensive Drugs Per Claim

Spinraza
Nusinersen
$73,000.00
per claim
Soliris
Eculizumab
$68,556.00
per claim
Ultomiris
Ravulizumab
$65,292.00
per claim
Hemlibra
Emicizumab
$34,278.00
per claim
Evrysdi
Risdiplam
$31,500.00
per claim
Eloctate
Antihemophilic Factor (FC fusion)
$31,500.00
per claim
Alprolix
Coagulation Factor IX (FC fusion)
$28,750.00
per claim
Mavyret
Glecaprevir/Pibrentasvir
$26,250.00
per claim
Epclusa
Sofosbuvir/Velpatasvir
$26,143.00
per claim
Advate
Antihemophilic Factor (rDNA)
$25,333.00
per claim
See all most expensive drugs →

Full A–Z Drug Index

ABCDEFGHIJKLMNOPQRSTUVWXYZ

A (37)

B (25)

C (32)

D (20)

E (23)

F (14)

G (11)

H (9)

I (16)

J (8)

K (10)

L (31)

M (19)

N (23)

O (23)

P (25)

Q (5)

R (28)

S (42)

T (39)

U (4)

V (28)

W (4)

X (12)

Y (1)

Z (11)

Frequently Asked Questions

DrugPrice tracks 507 prescription drugs from the CMS Medicare Part D Drug Spending Dashboard, representing $355.8B in annual spending across 231,460,840 beneficiaries.

All pricing data comes from the public CMS Medicare Part D Drug Spending Dashboard, which publishes aggregated spending, claims counts, and beneficiary counts for every drug reimbursed by Medicare. Patent and generic status comes from the FDA Orange Book.

Average cost per claim is the total Medicare Part D spending for a drug divided by the number of prescriptions filled. It approximates the cost of a typical 30-day supply, including both what Medicare pays and patient out-of-pocket costs.

The CMS dataset is refreshed annually. DrugPrice was last updated April 2026.

Sources: CMS Medicare Part D Drug Spending Dashboard, FDA Orange Book
Last updated:

Cost per claim is total Medicare spending divided by total prescriptions filled. Generic availability from FDA Orange Book.