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DrugPrice

Entresto

Sacubitril/Valsartan

Brand onlyHeart Failureby Novartis
$379.00
avg cost per claim
+18.3% year-over-year
$4.8B
Medicare Spending
12,560,000
Total Claims
1,085,000
Beneficiaries
$4,392.00
Annual Cost/Patient

Why Entresto Costs $379.00 Per Claim

Entresto (Sacubitril/Valsartan) is used to treat heart failure. According to CMS Medicare Part D spending data, the program spent $4.8B on this drug, covering 1,085,000 beneficiaries across 12,560,000 claims.

This drug is currently protected by patents expiring Nov 11, 2026. Until patent protection ends, no generic version can enter the market, which limits price competition. Once generics become available, the price typically drops 80-95%.

Spending on Entresto increased by +18.3% year-over-year, driven by increased utilization among Medicare beneficiaries.

Price Breakdown

Avg cost per claim (30-day)$379.00
Avg annual cost per patient$4,392.00
Total Medicare spending$4.8B
Total claims12,560,000
Beneficiaries1,085,000

Drug Details

Brand Name
Entresto
Generic Name
Sacubitril/Valsartan
Active Ingredient
SACUBITRIL, VALSARTAN
Manufacturer
Novartis
Dosage Form
TABLET
Route
ORAL
Condition
Heart Failure
FDA Application
NDA207620

Frequently Asked Questions

Entresto (Sacubitril/Valsartan) costs an average of $379.00 per claim based on Medicare Part D data. The estimated annual cost per patient is $4,392.00. Actual out-of-pocket costs depend on your insurance plan and pharmacy.

No, Entresto is currently brand-only. Patent protection expires Nov 11, 2026, after which generic versions may enter the market.

Medicare Part D spent $4.8B on Entresto, covering 1,085,000 beneficiaries across 12,560,000 claims. This makes it one of the tracked drugs in the Medicare spending dashboard.

Check manufacturer patient assistance programs for potential savings. You can also compare prices at different pharmacies, use prescription discount programs, or ask your doctor about therapeutic alternatives in the same drug class.

Cost data reflects Medicare Part D spending and may not represent retail pharmacy prices. Average cost per claim represents the total drug cost (not patient out-of-pocket) divided by total claims.