Dupixent vs Trulicity
Side-by-side drug price comparison from Medicare Part D data
Verdict
Trulicity costs 83% less per claim than Dupixent ($473.00 vs $2819.00). Neither drug has a generic alternative available. Total Medicare spending: Dupixent at $4.4B vs Trulicity at $4.2B.
| Metric | Dupixent | Trulicity |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $2,819 | $473* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $4.4B | $4.2B |
| Total Claims | 1,560,000 | 8,920,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 35.2% | -4.8%* |
| Generic Available | No | No |
| Condition | Autoimmune Diseases | Diabetes |
| Total Beneficiaries | 245,000 | 985,000 |
Trulicity costs 83% less per claim than Dupixent ($473.00 vs $2819.00). Neither drug has a generic alternative available. Total Medicare spending: Dupixent at $4.4B vs Trulicity at $4.2B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both entity A and entity B. What follows is the interpretation — which specific axes carry the most weight for entity A versus entity B, and which differences are large enough to influence a real decision.
Practical use of the comparison: read the data above, then drill into the individual entity A and entity B detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.