Eliquis vs Humira
Side-by-side drug price comparison from Medicare Part D data
Verdict
Eliquis costs 85% less per claim than Humira ($510.00 vs $3414.00). Eliquis has a generic alternative available. Total Medicare spending: Eliquis at $16.6B vs Humira at $6.5B.
| Metric | Eliquis | Humira |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $510* | $3,414 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $16.6B | $6.5B |
| Total Claims | 32,460,000 | 1,890,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 14.2% | -22.1%* |
| Generic Available | Yes | Yes |
| Condition | Blood Clots | Autoimmune Diseases |
| Total Beneficiaries | 3,850,000 | 195,000 |
Eliquis costs 85% less per claim than Humira ($510.00 vs $3414.00). Eliquis has a generic alternative available. Total Medicare spending: Eliquis at $16.6B vs Humira at $6.5B.
Explore More
Comparing Eliquis and Humira on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
Practical use of the comparison: read the data above, then drill into the individual Eliquis and Humira detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.