Imbruvica vs Calquence
Side-by-side drug price comparison from Medicare Part D data
Verdict
Calquence costs 3% less per claim than Imbruvica ($10105.00 vs $10445.00). Imbruvica has a generic alternative available. Total Medicare spending: Imbruvica at $5.7B vs Calquence at $2.9B.
| Metric | Imbruvica | Calquence |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $10,445 | $10,105* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.7B | $2.9B |
| Total Claims | 548,000 | 286,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | -8.7%* | 34.2% |
| Generic Available | Yes | Yes |
| Condition | Cancer | Cancer |
| Total Beneficiaries | 48,000 | 28,000 |
Calquence costs 3% less per claim than Imbruvica ($10105.00 vs $10445.00). Imbruvica has a generic alternative available. Total Medicare spending: Imbruvica at $5.7B vs Calquence at $2.9B.
Explore More
Comparing Imbruvica and Calquence on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.