Keytruda vs Calquence
Side-by-side drug price comparison from Medicare Part D data
Verdict
Calquence costs 44% less per claim than Keytruda ($10105.00 vs $18176.00). Calquence has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Calquence at $2.9B.
| Metric | Keytruda | Calquence |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $18,176 | $10,105* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $7.2B | $2.9B |
| Total Claims | 398,000 | 286,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 28.6%* | 34.2% |
| Generic Available | No | Yes |
| Condition | Cancer | Cancer |
| Total Beneficiaries | 82,000 | 28,000 |
Calquence costs 44% less per claim than Keytruda ($10105.00 vs $18176.00). Calquence has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Calquence at $2.9B.
Explore More
Comparing Keytruda and Calquence on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
Practical use of the comparison: read the data above, then drill into the individual Keytruda and Calquence detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.