Keytruda vs Cosentyx
Side-by-side drug price comparison from Medicare Part D data
Verdict
Cosentyx costs 80% less per claim than Keytruda ($3616.00 vs $18176.00). Cosentyx has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Cosentyx at $3.1B.
| Metric | Keytruda | Cosentyx |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $18,176 | $3,616* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $7.2B | $3.1B |
| Total Claims | 398,000 | 864,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 28.6% | 8.9%* |
| Generic Available | No | Yes |
| Condition | Cancer | Autoimmune Diseases |
| Total Beneficiaries | 82,000 | 120,000 |
Cosentyx costs 80% less per claim than Keytruda ($3616.00 vs $18176.00). Cosentyx has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Cosentyx at $3.1B.
Explore More
Comparing Keytruda and Cosentyx on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
Practical use of the comparison: read the data above, then drill into the individual Keytruda and Cosentyx detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.