Keytruda vs Mounjaro
Side-by-side drug price comparison from Medicare Part D data
Verdict
Mounjaro costs 96% less per claim than Keytruda ($673.00 vs $18176.00). Neither drug has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Mounjaro at $2.5B.
| Metric | Keytruda | Mounjaro |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $18,176 | $673* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $7.2B | $2.5B |
| Total Claims | 398,000 | 3,680,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 28.6%* | 312.4% |
| Generic Available | No | No |
| Condition | Cancer | Diabetes |
| Total Beneficiaries | 82,000 | 524,000 |
Mounjaro costs 96% less per claim than Keytruda ($673.00 vs $18176.00). Neither drug has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Mounjaro at $2.5B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Keytruda and Mounjaro. What follows is the interpretation — which specific axes carry the most weight for Keytruda versus Mounjaro, and which differences are large enough to influence a real decision.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.