Keytruda vs Xtandi
Side-by-side drug price comparison from Medicare Part D data
Verdict
Xtandi costs 49% less per claim than Keytruda ($9331.00 vs $18176.00). Xtandi has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Xtandi at $4.1B.
| Metric | Keytruda | Xtandi |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $18,176 | $9,331* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $7.2B | $4.1B |
| Total Claims | 398,000 | 438,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 28.6% | 9.4%* |
| Generic Available | No | Yes |
| Condition | Cancer | Cancer |
| Total Beneficiaries | 82,000 | 46,000 |
Xtandi costs 49% less per claim than Keytruda ($9331.00 vs $18176.00). Xtandi has a generic alternative available. Total Medicare spending: Keytruda at $7.2B vs Xtandi at $4.1B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both entity A and entity B. What follows is the interpretation — which specific axes carry the most weight for entity A versus entity B, and which differences are large enough to influence a real decision.
Practical use of the comparison: read the data above, then drill into the individual entity A and entity B detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.