Opdivo vs Xarelto
Side-by-side drug price comparison from Medicare Part D data
Verdict
Xarelto costs 98% less per claim than Opdivo ($321.00 vs $15821.00). Opdivo has a generic alternative available. Total Medicare spending: Opdivo at $5.1B vs Xarelto at $5.0B.
| Metric | Opdivo | Xarelto |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $15,821 | $321* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.1B | $5.0B |
| Total Claims | 324,000 | 15,680,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 15.8% | -1.2%* |
| Generic Available | Yes | Yes |
| Condition | Cancer | Blood Clots |
| Total Beneficiaries | 66,000 | 1,920,000 |
Xarelto costs 98% less per claim than Opdivo ($321.00 vs $15821.00). Opdivo has a generic alternative available. Total Medicare spending: Opdivo at $5.1B vs Xarelto at $5.0B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Opdivo and Xarelto. What follows is the interpretation — which specific axes carry the most weight for Opdivo versus Xarelto, and which differences are large enough to influence a real decision.
Practical use of the comparison: read the data above, then drill into the individual Opdivo and Xarelto detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.