Opdivo vs Xtandi
Side-by-side drug price comparison from Medicare Part D data
Verdict
Xtandi costs 41% less per claim than Opdivo ($9331.00 vs $15821.00). Opdivo has a generic alternative available. Total Medicare spending: Opdivo at $5.1B vs Xtandi at $4.1B.
| Metric | Opdivo | Xtandi |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $15,821 | $9,331* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.1B | $4.1B |
| Total Claims | 324,000 | 438,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 15.8% | 9.4%* |
| Generic Available | Yes | Yes |
| Condition | Cancer | Cancer |
| Total Beneficiaries | 66,000 | 46,000 |
Xtandi costs 41% less per claim than Opdivo ($9331.00 vs $15821.00). Opdivo has a generic alternative available. Total Medicare spending: Opdivo at $5.1B vs Xtandi at $4.1B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Opdivo and Xtandi. What follows is the interpretation — which specific axes carry the most weight for Opdivo versus Xtandi, and which differences are large enough to influence a real decision.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.