Ozempic vs Darzalex
Side-by-side drug price comparison from Medicare Part D data
Verdict
Ozempic costs 94% less per claim than Darzalex ($685.00 vs $11346.00). Darzalex has a generic alternative available. Total Medicare spending: Ozempic at $5.0B vs Darzalex at $3.2B.
| Metric | Ozempic | Darzalex |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $685* | $11,346 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.0B | $3.2B |
| Total Claims | 7,240,000 | 286,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 72.5% | 21.4%* |
| Generic Available | No | Yes |
| Condition | Diabetes | Cancer |
| Total Beneficiaries | 1,180,000 | 32,000 |
Ozempic costs 94% less per claim than Darzalex ($685.00 vs $11346.00). Darzalex has a generic alternative available. Total Medicare spending: Ozempic at $5.0B vs Darzalex at $3.2B.
Explore More
Comparing Ozempic and Darzalex on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.