Ozempic vs Trulicity
Side-by-side drug price comparison from Medicare Part D data
Verdict
Trulicity costs 31% less per claim than Ozempic ($473.00 vs $685.00). Neither drug has a generic alternative available. Total Medicare spending: Ozempic at $5.0B vs Trulicity at $4.2B.
| Metric | Ozempic | Trulicity |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $685 | $473* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.0B | $4.2B |
| Total Claims | 7,240,000 | 8,920,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 72.5% | -4.8%* |
| Generic Available | No | No |
| Condition | Diabetes | Diabetes |
| Total Beneficiaries | 1,180,000 | 985,000 |
Trulicity costs 31% less per claim than Ozempic ($473.00 vs $685.00). Neither drug has a generic alternative available. Total Medicare spending: Ozempic at $5.0B vs Trulicity at $4.2B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both entity A and entity B. What follows is the interpretation — which specific axes carry the most weight for entity A versus entity B, and which differences are large enough to influence a real decision.
Practical use of the comparison: read the data above, then drill into the individual entity A and entity B detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.