Stelara vs Darzalex
Side-by-side drug price comparison from Medicare Part D data
Verdict
Stelara costs 32% less per claim than Darzalex ($7763.00 vs $11346.00). Stelara has a generic alternative available. Total Medicare spending: Stelara at $5.6B vs Darzalex at $3.2B.
| Metric | Stelara | Darzalex |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $7,763* | $11,346 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.6B | $3.2B |
| Total Claims | 720,000 | 286,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 6.3%* | 21.4% |
| Generic Available | Yes | Yes |
| Condition | Autoimmune Diseases | Cancer |
| Total Beneficiaries | 114,000 | 32,000 |
Stelara costs 32% less per claim than Darzalex ($7763.00 vs $11346.00). Stelara has a generic alternative available. Total Medicare spending: Stelara at $5.6B vs Darzalex at $3.2B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Stelara and Darzalex. What follows is the interpretation — which specific axes carry the most weight for Stelara versus Darzalex, and which differences are large enough to influence a real decision.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.