Stelara vs Dupixent
Side-by-side drug price comparison from Medicare Part D data
Verdict
Dupixent costs 64% less per claim than Stelara ($2819.00 vs $7763.00). Stelara has a generic alternative available. Total Medicare spending: Stelara at $5.6B vs Dupixent at $4.4B.
| Metric | Stelara | Dupixent |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $7,763 | $2,819* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.6B | $4.4B |
| Total Claims | 720,000 | 1,560,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 6.3%* | 35.2% |
| Generic Available | Yes | No |
| Condition | Autoimmune Diseases | Autoimmune Diseases |
| Total Beneficiaries | 114,000 | 245,000 |
Dupixent costs 64% less per claim than Stelara ($2819.00 vs $7763.00). Stelara has a generic alternative available. Total Medicare spending: Stelara at $5.6B vs Dupixent at $4.4B.
Explore More
Comparing Stelara and Dupixent on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
Practical use of the comparison: read the data above, then drill into the individual Stelara and Dupixent detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.