Stelara vs Xtandi
Side-by-side drug price comparison from Medicare Part D data
Verdict
Stelara costs 17% less per claim than Xtandi ($7763.00 vs $9331.00). Stelara has a generic alternative available. Total Medicare spending: Stelara at $5.6B vs Xtandi at $4.1B.
| Metric | Stelara | Xtandi |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $7,763* | $9,331 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.6B | $4.1B |
| Total Claims | 720,000 | 438,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 6.3%* | 9.4% |
| Generic Available | Yes | Yes |
| Condition | Autoimmune Diseases | Cancer |
| Total Beneficiaries | 114,000 | 46,000 |
Stelara costs 17% less per claim than Xtandi ($7763.00 vs $9331.00). Stelara has a generic alternative available. Total Medicare spending: Stelara at $5.6B vs Xtandi at $4.1B.
Explore More
Comparing Stelara and Xtandi on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.