Trulicity vs Calquence
Side-by-side drug price comparison from Medicare Part D data
Verdict
Trulicity costs 95% less per claim than Calquence ($473.00 vs $10105.00). Calquence has a generic alternative available. Total Medicare spending: Trulicity at $4.2B vs Calquence at $2.9B.
| Metric | Trulicity | Calquence |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $473* | $10,105 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $4.2B | $2.9B |
| Total Claims | 8,920,000 | 286,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | -4.8%* | 34.2% |
| Generic Available | No | Yes |
| Condition | Diabetes | Cancer |
| Total Beneficiaries | 985,000 | 28,000 |
Trulicity costs 95% less per claim than Calquence ($473.00 vs $10105.00). Calquence has a generic alternative available. Total Medicare spending: Trulicity at $4.2B vs Calquence at $2.9B.
Explore More
Comparing Trulicity and Calquence on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.