Trulicity vs Darzalex
Side-by-side drug price comparison from Medicare Part D data
Verdict
Trulicity costs 96% less per claim than Darzalex ($473.00 vs $11346.00). Darzalex has a generic alternative available. Total Medicare spending: Trulicity at $4.2B vs Darzalex at $3.2B.
| Metric | Trulicity | Darzalex |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $473* | $11,346 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $4.2B | $3.2B |
| Total Claims | 8,920,000 | 286,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | -4.8%* | 21.4% |
| Generic Available | No | Yes |
| Condition | Diabetes | Cancer |
| Total Beneficiaries | 985,000 | 32,000 |
Trulicity costs 96% less per claim than Darzalex ($473.00 vs $11346.00). Darzalex has a generic alternative available. Total Medicare spending: Trulicity at $4.2B vs Darzalex at $3.2B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Trulicity and Darzalex. What follows is the interpretation — which specific axes carry the most weight for Trulicity versus Darzalex, and which differences are large enough to influence a real decision.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.