Seizure/Epilepsy Drug Costs With Medicare
Compare 17 seizure/epilepsy drug prices under Medicare Part D, averaging $880.18 per claim. Prices range from $19.00 (Topiramate) to $4,944.00 (Diacomit) per prescription. 17 of 17 drugs have FDA-approved generics that cost 30-80% less.
Key Facts: Seizure/Epilepsy Drug Costs
- Cheapest drug
- Topiramate ($19.00)
- Most expensive
- Diacomit ($4,944.00)
- Medicare Part D avg
- $880.18/claim
- Generics available
- 17 of 17
- Total Medicare spend
- $3.8B/yr
- Brand-only drugs
- 0
Source: CMS Medicare Part D Spending, latest reporting year. Costs reflect plan-paid amounts, not patient out-of-pocket.
Seizure/Epilepsy Drug Price Comparison
All 17 seizure/epilepsy drugs tracked in Medicare Part D, sorted from cheapest to most expensive. Click any drug for Medicare coverage details, generic timelines, and savings options.
| Drug | Generic Name | Medicare Avg/Claim | Generic Available? |
|---|---|---|---|
| Topiramate | Topiramate | $19.00 | Yes |
| Levetiracetam | Levetiracetam | $21.00 | Yes |
| Divalproex | Divalproex Sodium | $30.00 | Yes |
| Carbamazepine | Carbamazepine | $36.00 | Yes |
| Phenytoin | Phenytoin Sodium | $36.00 | Yes |
| Oxcarbazepine | Oxcarbazepine | $48.00 | Yes |
| Zonisamide | Zonisamide | $54.00 | Yes |
| Vimpat | Lacosamide | $270.00 | Yes |
| Aptiom | Eslicarbazepine | $375.00 | Yes |
| Briviact | Brivaracetam | $399.00 | Yes |
| Fycompa | Perampanel | $552.00 | Yes |
| Xcopri | Cenobamate | $553.00 | Yes |
| Onfi | Clobazam | $718.00 | Yes |
| Banzel | Rufinamide | $831.00 | Yes |
| Epidiolex | Cannabidiol | $1,839.00 | Yes |
| Sabril | Vigabatrin | $4,238.00 | Yes |
| Diacomit | Stiripentol | $4,944.00 | Yes |
Medicare Part D Coverage for Seizure/Epilepsy Drugs
All 17 seizure/epilepsy drugs in this comparison are dispensed under Medicare Part D. Total Medicare spending reached $3.8B in the latest reporting year, averaging $880.18 per prescription fill.
Your out-of-pocket cost depends on three factors: (1) your plan's formulary tier — generics typically land on Tier 1 ($0-$10 copay), preferred brands on Tier 2 ($30-$50), and specialty drugs on Tier 4-5 (often 25-33% coinsurance); (2) your deductible status — most plans require you to meet up to a $590 deductible before copays apply; (3) the coverage phase — initial coverage, coverage gap, or catastrophic. As of 2025, Medicare Part D caps total annual out-of-pocket at $2,000 under the Inflation Reduction Act.
The 17 drugs with generic availability are usually the most cost-effective starting point — ask your prescriber whether a generic substitution is clinically appropriate.
Drug costs vary dramatically within this category. Diacomit (Stiripentol) at $4,944.00 per claim is 260x more expensive than Topiramate (Topiramate) at $19.00 — yet both treat seizure/epilepsy. Therapeutic substitution within the same drug class is often the single biggest savings lever, and it requires only a prescriber conversation, not a plan change.
Frequently Asked Questions
Medicare Part D pays an average of $880.18 per claim for seizure/epilepsy medications across 17 tracked drugs. Patient out-of-pocket costs depend on your plan's formulary tier, deductible, and whether you've reached the catastrophic coverage phase. Most seizure/epilepsy drugs fall on Tier 2 (preferred brand) or Tier 3 (non-preferred brand) of standard Medicare Part D formularies.
The least expensive seizure/epilepsy medication is Topiramate (Topiramate) at $19.00 per Medicare Part D claim. A generic version is FDA-approved and available — ask your pharmacist about substitution to lower copays further.
Yes. All 17 seizure/epilepsy drugs tracked here appear in Medicare Part D claims data, meaning they are dispensed under Part D plans. Coverage details — formulary tier, prior authorization requirements, step therapy — vary by plan. Check your plan's formulary or call 1-800-MEDICARE before filling.
Yes, 17 of 17 seizure/epilepsy drugs have FDA-approved generic alternatives. Generics contain the same active ingredient and meet bioequivalence standards, but typically cost 30-80% less. On Medicare Part D, generics usually fall on Tier 1 with the lowest copay.
Three primary strategies: (1) Switch to a generic if available — Tier 1 generics typically cost under $10 per fill on Medicare Part D; (2) Use manufacturer copay assistance for brand-name drugs (commercial insurance only — Medicare beneficiaries can apply for patient assistance foundations like NeedyMeds or the PAN Foundation); (3) Compare cash prices using GoodRx, SingleCare, or Mark Cuban's Cost Plus Drugs — sometimes cash pay beats your Part D copay. Talk to your doctor about therapeutic alternatives in the same drug class.
Related Conditions
Cost per claim is the average plan-paid amount per prescription fill under Medicare Part D. Patient out-of-pocket varies by formulary tier and deductible status. Generic availability is based on FDA Orange Book data.
Source: CMS Medicare Part D Spending, 2026.