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Specialty Drug

A high-cost medication — typically above $1,000 per month — that treats complex or chronic conditions and often requires special handling, storage, or administration.

How It Works

Specialty drugs represent less than 2% of all prescriptions but account for over 50% of total drug spending in the United States. They include biologics, cancer treatments, autoimmune therapies, and gene therapies. Specialty drugs often require refrigeration, injection or infusion, and close monitoring by a healthcare provider. Insurers typically place specialty drugs on the highest formulary tier with the greatest cost-sharing. Patient assistance programs and specialty pharmacies exist specifically to help patients access and afford these medications.

Related Terms

  • Biologic DrugA complex medication derived from living cells — including monoclonal antibodies, vaccines, and cell therapies — that treats serious conditions like cancer and autoimmune diseases.
  • FormularyA list of prescription drugs covered by an insurance plan, organized into tiers that determine how much the patient pays for each drug.
  • Prior AuthorizationA requirement by an insurer that a patient's doctor must get approval before the plan will cover a specific drug — used to control costs and ensure appropriate use.

About This Definition

This definition is part of the DrugPrice Drug Pricing Glossary34 terms explaining how prescription drug pricing works in the United States. All definitions are written in plain language for patients, caregivers, journalists, and healthcare professionals.