Pfizer, Drug Prices & Medicare Spending

Pfizer manufactures 32 drugs tracked by Medicare Part D with total spending of $14.7B.

Drugs Tracked

$14.7B

Medicare Spending

$85.17

Avg Cost/Claim

100%

Have Generics

Pfizer Drugs, Ranked by Medicare Spending

#	Drug	Generic Name	Cost/Claim	Medicare Spending	YoY Change	Generic?
1	Ibrance	Palbociclib	$10,816.00	$4.5B	-5.6%	Yes
2	Xeljanz	Tofacitinib	$1,685.00	$1.5B	-8.9%	Yes
3	Nurtec ODT	Rimegepant	$353.00	$876.0M	+68.4%	Yes
4	Lyrica	Pregabalin	$84.00	$723.0M	-42.5%	Yes
5	Sutent	Sunitinib	$11,813.00	$567.0M	-12.4%	Yes
6	Inlyta	Axitinib	$10,125.00	$567.0M	+8.4%	Yes
7	Lipitor	Atorvastatin	$16.00	$456.0M	-56.3%	Yes
8	Lorbrena	Lorlatinib	$14,250.00	$456.0M	+42.5%	Yes
9	Braftovi	Encorafenib	$12,667.00	$456.0M	+18.4%	Yes
10	Genotropin	Somatropin	$2,303.00	$456.0M	-8.6%	Yes
11	Celebrex	Celecoxib	$53.00	$345.0M	-42.1%	Yes
12	Bosulif	Bosutinib	$8,214.00	$345.0M	+3.4%	Yes
13	Pristiq	Desvenlafaxine	$139.00	$345.0M	-24.6%	Yes
14	Pregabalin	Pregabalin	$40.00	$345.0M	-32.4%	Yes
15	Gabapentin	Gabapentin	$12.00	$234.0M	-22.4%	Yes
16	Zyvox	Linezolid	$375.00	$234.0M	-18.4%	Yes
17	Rapamune	Sirolimus	$375.00	$234.0M	-8.4%	Yes
18	Xalkori	Crizotinib	$13,000.00	$234.0M	-14.2%	Yes
19	Vfend	Voriconazole	$1,435.00	$178.0M	-12.4%	Yes
20	Mektovi	Binimetinib	$9,889.00	$178.0M	+6.8%	Yes
21	Eucrisa	Crisaborole	$285.00	$178.0M	-14.2%	Yes
22	Amlodipine	Amlodipine Besylate	$6.00	$145.0M	-34.6%	Yes
23	Sertraline	Sertraline Hydrochloride	$10.00	$145.0M	-28.4%	Yes
24	Venlafaxine	Venlafaxine Hydrochloride	$17.00	$145.0M	-28.6%	Yes
25	Pantoprazole	Pantoprazole Sodium	$10.00	$145.0M	-22.4%	Yes
26	Protonix	Pantoprazole (brand)	$58.00	$145.0M	-28.6%	Yes
27	Latanoprost	Latanoprost	$25.00	$123.0M	-22.4%	Yes
28	Azithromycin	Azithromycin	$10.00	$89.0M	-18.6%	Yes
29	Clindamycin	Clindamycin	$18.00	$89.0M	-14.2%	Yes
30	Ziprasidone	Ziprasidone	$48.00	$89.0M	-24.4%	Yes
31	Eplerenone	Eplerenone	$48.00	$89.0M	-14.2%	Yes
32	Fluconazole	Fluconazole	$14.00	$67.0M	-14.2%	Yes

Frequently Asked Questions

Pfizer manufactures 32 drugs tracked by Medicare Part D, with total annual spending of $14.7B.

Lorbrena (Lorlatinib) is the most expensive at $14,250.00 per claim.

32 of 32 Pfizer drugs (100%) have generic alternatives available. Generic drugs can save patients 30-80% compared to brand-name versions.

For this entity, the underlying data on this page comes from CMS Medicare Part D Drug Spending data. The breakdown above is the federal record; the paragraphs below add the per-entity context that makes the headline numbers usable for a real decision rather than just a data lookup.

The methodology behind every numeric value on this page is publicly documented on the CMS Medicare Part D Drug Spending data portal and described in detail on this site’s methodology page. Refresh cadence varies by underlying series; the page surfaces the as-of date for each number so readers can trace any figure back to the source release.

For readers using this page as a decision input, the related-entity pages elsewhere on the site provide the comparison set. The most useful comparison for this entity is typically a peer within U.S. prescription drugs with similar size, similar exposure, or similar geography — not the national-level summary alone.

Source: CMS Medicare Part D Spending, 2026.