Various, Drug Prices & Medicare Spending

Various manufactures 33 drugs tracked by Medicare Part D with total spending of $4.0B.

Drugs Tracked

$4.0B

Medicare Spending

$12.51

Avg Cost/Claim

100%

Have Generics

Various Drugs, Ranked by Medicare Spending

#	Drug	Generic Name	Cost/Claim	Medicare Spending	YoY Change	Generic?
1	Tacrolimus	Tacrolimus	$139.00	$345.0M	-8.4%	Yes
2	Levothyroxine	Levothyroxine Sodium	$8.00	$234.0M	-12.6%	Yes
3	Mycophenolate	Mycophenolate Mofetil	$94.00	$234.0M	-12.6%	Yes
4	Lisinopril	Lisinopril	$6.00	$178.0M	-32.4%	Yes
5	Oxycodone	Oxycodone Hydrochloride	$27.00	$178.0M	-24.6%	Yes
6	Vancomycin	Vancomycin Hydrochloride	$144.00	$178.0M	-4.2%	Yes
7	Metformin	Metformin Hydrochloride	$4.00	$145.0M	-18.6%	Yes
8	Hydrocodone	Hydrocodone/Acetaminophen	$10.00	$145.0M	-18.4%	Yes
9	Carbidopa-Levodopa	Carbidopa/Levodopa	$17.00	$145.0M	-8.4%	Yes
10	Trazodone	Trazodone Hydrochloride	$8.00	$123.0M	-18.4%	Yes
11	Spironolactone	Spironolactone	$14.00	$123.0M	-12.4%	Yes
12	Doxycycline	Doxycycline Hyclate	$14.00	$123.0M	-8.4%	Yes
13	Morphine	Morphine Sulfate	$25.00	$123.0M	-22.4%	Yes
14	Diltiazem	Diltiazem Hydrochloride	$19.00	$123.0M	-18.6%	Yes
15	Hydrochlorothiazide	Hydrochlorothiazide	$4.00	$89.0M	-14.2%	Yes
16	Atenolol	Atenolol	$10.00	$89.0M	-18.4%	Yes
17	Tramadol	Tramadol Hydrochloride	$6.00	$89.0M	-18.6%	Yes
18	Allopurinol	Allopurinol	$10.00	$89.0M	-14.2%	Yes
19	Cephalexin	Cephalexin	$10.00	$89.0M	-14.2%	Yes
20	Amoxicillin	Amoxicillin	$8.00	$89.0M	-12.4%	Yes
21	Nitrofurantoin	Nitrofurantoin Monohydrate	$14.00	$89.0M	-8.6%	Yes
22	Prednisone	Prednisone	$6.00	$89.0M	-8.4%	Yes
23	Verapamil	Verapamil Hydrochloride	$18.00	$89.0M	-22.4%	Yes
24	Ramipril	Ramipril	$18.00	$89.0M	-18.4%	Yes
25	Clonidine	Clonidine	$14.00	$89.0M	-12.4%	Yes
26	Propranolol	Propranolol Hydrochloride	$18.00	$89.0M	-14.6%	Yes
27	Buspirone	Buspirone Hydrochloride	$14.00	$89.0M	-8.4%	Yes
28	Mirtazapine	Mirtazapine	$14.00	$89.0M	-14.2%	Yes
29	Oxybutynin	Oxybutynin Chloride	$18.00	$89.0M	-14.2%	Yes
30	Calcitriol	Calcitriol	$36.00	$89.0M	-12.4%	Yes
31	Lithium	Lithium Carbonate	$48.00	$89.0M	-12.4%	Yes
32	Amitriptyline	Amitriptyline Hydrochloride	$10.00	$67.0M	-12.4%	Yes
33	Citalopram	Citalopram Hydrobromide	$10.00	$67.0M	-28.4%	Yes

Frequently Asked Questions

Various manufactures 33 drugs tracked by Medicare Part D, with total annual spending of $4.0B.

Vancomycin (Vancomycin Hydrochloride) is the most expensive at $144.00 per claim.

33 of 33 Various drugs (100%) have generic alternatives available. Generic drugs can save patients 30-80% compared to brand-name versions.

this entity is one of the data points covered by this site’s U.S. Medicare prescription-drug pricing dataset. The detail above comes directly from CMS Medicare Part D Drug Spending data; the context that follows situates the headline numbers against the broader distribution across U.S. prescription drugs.

Every number on this page links back to CMS Medicare Part D Drug Spending data; the methodology page describes the inputs, refresh cadence, and known limitations of the underlying data product.

Practical use of this page is in combination with the comparison and ranking pages elsewhere on the site, which surface the same data for this entity’s peers within U.S. prescription drugs. A single-entity reading without peer context can be misleading when an entity is an outlier on one axis but typical on another.

Source: CMS Medicare Part D Spending, 2026.