Darzalex vs Repatha
Side-by-side drug price comparison from Medicare Part D data
Verdict
Repatha costs 93% less per claim than Darzalex ($757.00 vs $11346.00). Darzalex has a generic alternative available. Total Medicare spending: Darzalex at $3.2B vs Repatha at $2.6B.
| Metric | Darzalex | Repatha |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $11,346 | $757* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $3.2B | $2.6B |
| Total Claims | 286,000 | 3,420,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 21.4%* | 24.6% |
| Generic Available | Yes | No |
| Condition | Cancer | High Cholesterol |
| Total Beneficiaries | 32,000 | 398,000 |
Repatha costs 93% less per claim than Darzalex ($757.00 vs $11346.00). Darzalex has a generic alternative available. Total Medicare spending: Darzalex at $3.2B vs Repatha at $2.6B.
Explore More
Comparing Darzalex and Repatha on U.S. Medicare prescription-drug pricing requires lining up the underlying CMS Medicare Part D Drug Spending data data side by side. The table above runs the comparison on the canonical fields; the narrative below identifies the factor or factors that drive the most meaningful difference between the two.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.