Entresto vs Eylea
Side-by-side drug price comparison from Medicare Part D data
Verdict
Entresto costs 50% less per claim than Eylea ($379.00 vs $752.00). Eylea has a generic alternative available. Total Medicare spending: Entresto at $4.8B vs Eylea at $3.7B.
| Metric | Entresto | Eylea |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $379* | $752 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $4.8B | $3.7B |
| Total Claims | 12,560,000 | 4,860,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 18.3% | -8.3%* |
| Generic Available | No | Yes |
| Condition | Heart Failure | Eye Diseases |
| Total Beneficiaries | 1,085,000 | 685,000 |
Entresto costs 50% less per claim than Eylea ($379.00 vs $752.00). Eylea has a generic alternative available. Total Medicare spending: Entresto at $4.8B vs Eylea at $3.7B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Entresto and Eylea. What follows is the interpretation — which specific axes carry the most weight for Entresto versus Eylea, and which differences are large enough to influence a real decision.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.