Ozempic vs Entresto
Side-by-side drug price comparison from Medicare Part D data
Verdict
Entresto costs 45% less per claim than Ozempic ($379.00 vs $685.00). Neither drug has a generic alternative available. Total Medicare spending: Ozempic at $5.0B vs Entresto at $4.8B.
| Metric | Ozempic | Entresto |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $685 | $379* |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.0B | $4.8B |
| Total Claims | 7,240,000 | 12,560,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | 72.5% | 18.3%* |
| Generic Available | No | No |
| Condition | Diabetes | Heart Failure |
| Total Beneficiaries | 1,180,000 | 1,085,000 |
Entresto costs 45% less per claim than Ozempic ($379.00 vs $685.00). Neither drug has a generic alternative available. Total Medicare spending: Ozempic at $5.0B vs Entresto at $4.8B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both Ozempic and Entresto. What follows is the interpretation — which specific axes carry the most weight for Ozempic versus Entresto, and which differences are large enough to influence a real decision.
For households or analysts using this comparison as a decision input, the right framing is usually not "which is better" in aggregate but "which is better for the specific decision in front of you." CMS Medicare Part D Drug Spending data captures the raw data; the framing depends on whether the question is investment, residency, planning, or research.
Source: CMS Medicare Part D Spending, 2026.