Xarelto vs Entresto
Side-by-side drug price comparison from Medicare Part D data
Verdict
Xarelto costs 15% less per claim than Entresto ($321.00 vs $379.00). Xarelto has a generic alternative available. Total Medicare spending: Xarelto at $5.0B vs Entresto at $4.8B.
| Metric | Xarelto | Entresto |
|---|---|---|
| Avg Cost per Claim Average cost Medicare pays per prescription claim | $321* | $379 |
| Total Medicare Spending Total Medicare Part D spending on this drug | $5.0B | $4.8B |
| Total Claims | 15,680,000 | 12,560,000 |
| Year-over-Year Change Price change from prior year (lower is better for patients) | -1.2%* | 18.3% |
| Generic Available | Yes | No |
| Condition | Blood Clots | Heart Failure |
| Total Beneficiaries | 1,920,000 | 1,085,000 |
Xarelto costs 15% less per claim than Entresto ($321.00 vs $379.00). Xarelto has a generic alternative available. Total Medicare spending: Xarelto at $5.0B vs Entresto at $4.8B.
Explore More
The side-by-side above pulls the CMS Medicare Part D Drug Spending data data for both entity A and entity B. What follows is the interpretation — which specific axes carry the most weight for entity A versus entity B, and which differences are large enough to influence a real decision.
Practical use of the comparison: read the data above, then drill into the individual entity A and entity B detail pages for the underlying breakdown. A pairwise comparison answers the relative question; the per-entity pages answer the absolute question.
Source: CMS Medicare Part D Spending, 2026.