Invega Sustenna vs Rexulti
Side-by-side cost comparison based on Medicare Part D data
Invega Sustenna
Paliperidone Palmitate
Manufactured by Janssen
Rexulti
Brexpiprazole
Manufactured by Otsuka
Rexulti costs 74% less per claim than Invega Sustenna ($396.00 vs $1,513.00). A generic version of Rexulti is also available, which may reduce costs further.
Cost Per Claim
Medicare Spending
Beneficiaries
Annual Cost Per Patient
Full Comparison
| Metric | Invega Sustenna | Rexulti |
|---|---|---|
| Avg Cost Per Claim | $1,513.00 | $396.00 |
| Total Medicare Spending | $1.9B | $1.2B |
| Total Beneficiaries | 148,000 | 356,000 |
| Total Claims | 1,240,000 | 3,120,000 |
| Annual Cost/Patient | $12,676.00 | $3,466.00 |
| Year-over-Year Change | +4.2% | +22.4% |
| Generic Available | Yes | Yes |
| Patent Expiration | Jan 31, 2023 | Jan 31, 2023 |
| Manufacturer | Janssen | Otsuka |
| Condition | Mental Health | Mental Health |
| Generic Name | Paliperidone Palmitate | Brexpiprazole |
Invega Sustenna vs Rexulti: What the Data Shows
Invega Sustenna (Paliperidone Palmitate) and Rexulti (Brexpiprazole) are both used to treat mental health. Based on Medicare Part D data, Rexulti costs $396.00 per claim, which is 74% less than Invega Sustenna at $1,513.00 per claim.
Medicare spent $1.9B on Invega Sustenna and $1.2B on Rexulti. In terms of patient reach, Rexulti serves more beneficiaries (356,000 vs 148,000).
Year-over-year spending changed +4.2% for Invega Sustenna and +22.4% for Rexulti. Rexulti saw significant spending growth, suggesting increased utilization or price increases.
Both drugs have generic versions available. Patients should discuss generic alternatives with their pharmacist to reduce out-of-pocket costs.
Frequently Asked Questions
Rexulti is cheaper at $396.00 per claim, compared to $1,513.00 for Invega Sustenna. That makes Rexulti about 74% less expensive per claim based on Medicare Part D data.
Yes, both Invega Sustenna and Rexulti are used to treat mental health. Your doctor can help determine which medication is more appropriate for your specific situation.
Both drugs have generic versions available. Generic Paliperidone Palmitate and generic Brexpiprazole can offer significant cost savings — typically 80-95% less than the brand name.
Medicare Part D spent $1.9B on Invega Sustenna covering 148,000 beneficiaries, and $1.2B on Rexulti covering 356,000 beneficiaries.
Explore Further
Cost data reflects Medicare Part D spending and may not represent retail pharmacy prices. Average cost per claim represents the total drug cost (not patient out-of-pocket) divided by total claims. This comparison is informational only and should not replace medical advice.