SnapshotUpdated April 2026
Most Expensive Medicare Drugs
The drugs costing Medicare the most each year
Eliquis is the most expensive Medicare drug at $16.6B in annual spending, followed by Revlimid.
| # | Name | Metric |
|---|---|---|
| 1 | Eliquis $16.6B total, $510/claim | $16.6B |
| 2 | Revlimid $7.8B total, $13K/claim | $7.8B |
| 3 | Keytruda $7.2B total, $18K/claim | $7.2B |
| 4 | Humira $6.5B total, $3K/claim | $6.5B |
| 5 | Imbruvica $5.7B total, $10K/claim | $5.7B |
| 6 | Stelara $5.6B total, $8K/claim | $5.6B |
| 7 | Opdivo $5.1B total, $16K/claim | $5.1B |
| 8 | Xarelto $5.0B total, $321/claim | $5.0B |
| 9 | Ozempic $5.0B total, $685/claim | $5.0B |
| 10 | Entresto $4.8B total, $379/claim | $4.8B |
Eliquis is the most expensive Medicare drug at $16.6B in annual spending, followed by Revlimid.
Frequently Asked Questions
This report is auto-generated from real public data sources. Entities are ranked by their key metrics and the most notable changes and extremes are highlighted.
The underlying data is refreshed on a regular schedule. This report was generated from the most recent available data (last updated April 2026).
The primary metric varies by report type. It may represent a score, dollar amount, rate, or count depending on what the report is measuring.
Source: CMS Medicare Part D Spending, 2026.