Drugs with Biggest Price Increases (2026)

The largest year-over-year increase is +312.4%. These 50 drugs have seen the most dramatic cost increases in Medicare Part D spending.

Reviewed by DrugPrice Editorial Team · Updated Apr 6, 2026

#	Drug	Condition	YoY Change	Cost/Claim	Medicare Spending	Generic?
1	Mounjaro Tirzepatide	Diabetes	+312.4%	$673.00	$2.5B	No
2	Leqvio Inclisiran	High Cholesterol	+186.4%	$1,391.00	$345.0M	Yes
3	Wegovy Semaglutide (weight)	Obesity	+185.6%	$820.00	$2.3B	Yes
4	Vabysmo Faricimab	Eye Diseases	+156.3%	$663.00	$1.2B	Yes
5	Enhertu Fam-Trastuzumab Deruxtecan	Cancer	+125.4%	$16,930.00	$1.5B	Yes
6	Tezspire Tezepelumab	Asthma/COPD	+124.6%	$3,081.00	$456.0M	Yes
7	Kerendia Finerenone	Kidney Disease	+124.6%	$399.00	$345.0M	Yes
8	Opzelura Ruxolitinib (topical)	Dermatology	+124.6%	$375.00	$234.0M	Yes
9	Brukinsa Zanubrutinib	Cancer	+86.5%	$9,952.00	$1.2B	Yes
10	Cabenuva Cabotegravir/Rilpivirine	HIV	+86.4%	$6,593.00	$567.0M	Yes
11	Opdualag Nivolumab/Relatlimab	Cancer	+86.4%	$13,500.00	$567.0M	Yes
12	Qulipta Atogepant	Migraine	+86.4%	$528.00	$456.0M	Yes
13	Quviviq Daridorexant	Sleep Disorders	+86.4%	$271.00	$234.0M	Yes
14	Padcev Enfortumab Vedotin	Cancer	+82.3%	$14,515.00	$987.0M	Yes
15	Ozempic Semaglutide	Diabetes	+72.5%	$685.00	$5.0B	No
16	Kesimpta Ofatumumab	Multiple Sclerosis	+68.4%	$8,425.00	$1.6B	Yes
17	Trodelvy Sacituzumab Govitecan	Cancer	+68.4%	$15,643.00	$876.0M	Yes
18	Nurtec ODT Rimegepant	Migraine	+68.4%	$353.00	$876.0M	Yes
19	Gemtesa Vibegron	Prostate/Urology	+68.4%	$278.00	$345.0M	Yes
20	Lybalvi Olanzapine/Samidorphan	Mental Health	+68.4%	$375.00	$234.0M	Yes
21	Saphnelo Anifrolumab	Autoimmune Diseases	+68.4%	$5,563.00	$178.0M	Yes
22	Xcopri Cenobamate	Seizure/Epilepsy	+56.4%	$553.00	$345.0M	Yes
23	Qelbree Viloxazine	ADHD	+56.4%	$271.00	$234.0M	Yes
24	Skytrofa Lonapegsomatropin	Growth Disorders	+56.4%	$3,441.00	$234.0M	Yes
25	Nexlizet Bempedoic Acid/Ezetimibe	High Cholesterol	+56.4%	$285.00	$178.0M	Yes
26	Rinvoq Upadacitinib	Autoimmune Diseases	+56.3%	$3,498.00	$2.3B	No
27	Retevmo Selpercatinib	Cancer	+56.3%	$14,375.00	$345.0M	Yes
28	Verquvo Vericiguat	Heart Failure	+56.3%	$511.00	$178.0M	Yes
29	Breztri Aerosphere Budesonide/Glycopyrrolate/Formoterol	Asthma/COPD	+48.3%	$305.00	$756.0M	No
30	Spravato Esketamine	Depression/Anxiety	+45.6%	$1,839.00	$456.0M	Yes
31	Nubeqa Darolutamide	Cancer	+45.3%	$7,910.00	$1.2B	Yes
32	Skyrizi Risankizumab	Autoimmune Diseases	+42.8%	$4,475.00	$2.3B	No
33	Evrysdi Risdiplam	Rare Diseases	+42.6%	$31,500.00	$567.0M	Yes
34	Dayvigo Lemborexant	Sleep Disorders	+42.6%	$185.00	$345.0M	Yes
35	Lorbrena Lorlatinib	Cancer	+42.5%	$14,250.00	$456.0M	Yes
36	Reblozyl Luspatercept	Anemia	+42.4%	$6,593.00	$567.0M	Yes
37	Narcan Naloxone Nasal Spray	Opioid Dependence	+42.4%	$144.00	$178.0M	Yes
38	Sogroya Somapacitan	Growth Disorders	+42.4%	$2,070.00	$178.0M	Yes
39	Adbry Tralokinumab	Dermatology	+42.4%	$718.00	$178.0M	Yes
40	Caplyta Lumateperone	Mental Health	+42.3%	$457.00	$567.0M	Yes
41	Semglee Insulin Glargine-yfgn	Diabetes	+42.3%	$139.00	$345.0M	Yes
42	Nexletol Bempedoic Acid	High Cholesterol	+42.3%	$271.00	$234.0M	Yes
43	Lupkynis Voclosporin	Autoimmune Diseases	+42.3%	$4,875.00	$234.0M	Yes
44	Rybelsus Semaglutide (oral)	Diabetes	+38.7%	$428.00	$1.8B	Yes
45	Libtayo Cemiplimab	Cancer	+35.6%	$14,125.00	$678.0M	Yes
46	Dupixent Dupilumab	Autoimmune Diseases	+35.2%	$2,819.00	$4.4B	No
47	Calquence Acalabrutinib	Cancer	+34.2%	$10,105.00	$2.9B	Yes
48	Dovato Dolutegravir/Lamivudine	HIV	+32.6%	$2,910.00	$1.2B	Yes
49	Ultomiris Ravulizumab	Blood Disorders	+32.4%	$65,292.00	$1.6B	Yes
50	Ubrelvy Ubrogepant	Migraine	+32.4%	$305.00	$567.0M	Yes

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Top 100 Medicare Drug Price Increases (2026)

The 100 biggest year-over-year price jumps in Medicare Part D — drug, manufacturer, cost per claim, and whether a generic exists yet. Enter your email to download the full ranked report (PDF; machine-readable CSV linked inside).

Frequently Asked Questions

Price increases stem from patent protection (no competition), limited generic alternatives, rebate structures with pharmacy benefit managers, annual manufacturer price hikes, and increasing demand. Brand-name drugs without generic competition see the steepest increases.

Check the "Generic?" column. If a generic is available, ask your doctor about switching. Also explore manufacturer patient assistance programs, GoodRx coupons, or Mark Cuban's Cost Plus Drugs for lower prices.

Year-over-year change compares the current year's average cost per claim to the prior year's average cost per claim under Medicare Part D, expressed as a percentage change.

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