Biggest Price Decreases

Drugs with the largest year-over-year price decreases. 100 drugs tracked with an average change of -29.4%.

100

Drugs

-29.4%

Avg Change

$28.3B

Total Spending

-56.3%

Top Change

Biggest Price Increases Biggest Price Decreases

Biggest Price Decreases — Ranked by Year-Over-Year Change

#	Drug	Generic Name	YoY Change	Cost/Claim	Medicare Spending	Generic?
1	Lipitor	Atorvastatin	-56.3%	$16.00	$456.0M	Yes
2	Crestor	Rosuvastatin	-48.2%	$28.00	$698.0M	Yes
3	Lyrica	Pregabalin	-42.5%	$84.00	$723.0M	Yes
4	Sovaldi	Sofosbuvir	-42.4%	$13,000.00	$234.0M	Yes
5	Aricept	Donepezil	-42.4%	$21.00	$178.0M	Yes
6	Plavix	Clopidogrel (brand)	-42.4%	$18.00	$89.0M	Yes
7	Cymbalta	Duloxetine	-42.3%	$19.00	$234.0M	Yes
8	Celebrex	Celecoxib	-42.1%	$53.00	$345.0M	Yes
9	Zetia	Ezetimibe	-38.7%	$21.00	$298.0M	Yes
10	Namenda	Memantine	-38.6%	$22.00	$145.0M	Yes
11	Abilify	Aripiprazole	-38.4%	$45.00	$567.0M	Yes
12	Seroquel	Quetiapine	-38.4%	$40.00	$345.0M	Yes
13	Singulair	Montelukast	-38.4%	$12.00	$145.0M	Yes
14	Harvoni	Ledipasvir/Sofosbuvir	-38.2%	$24,958.00	$1.2B	No
15	Amlodipine	Amlodipine Besylate	-34.6%	$6.00	$145.0M	Yes
16	Simvastatin	Simvastatin	-34.6%	$7.00	$123.0M	Yes
17	Copaxone	Glatiramer Acetate	-34.5%	$1,594.00	$456.0M	Yes
18	Vytorin	Ezetimibe/Simvastatin	-34.2%	$58.00	$145.0M	Yes
19	Prevacid	Lansoprazole	-34.2%	$50.00	$123.0M	Yes
20	Lovaza	Omega-3-Acid Ethyl Esters	-34.2%	$143.00	$89.0M	Yes
21	Aripiprazole	Aripiprazole	-32.6%	$27.00	$234.0M	Yes
22	Latuda	Lurasidone	-32.5%	$300.00	$1.4B	Yes
23	Truvada	Emtricitabine/Tenofovir DF	-32.4%	$2,066.00	$876.0M	Yes
24	Pregabalin	Pregabalin	-32.4%	$40.00	$345.0M	Yes
25	OxyContin	Oxycodone ER	-32.4%	$185.00	$345.0M	Yes
26	Nexium	Esomeprazole Magnesium	-32.4%	$48.00	$234.0M	Yes
27	Lisinopril	Lisinopril	-32.4%	$6.00	$178.0M	Yes
28	Escitalopram	Escitalopram Oxalate	-32.4%	$10.00	$123.0M	Yes
29	Warfarin	Warfarin Sodium	-32.4%	$10.00	$89.0M	Yes
30	Sustiva	Efavirenz	-32.4%	$1,854.00	$89.0M	Yes
31	Niaspan	Niacin ER	-32.4%	$143.00	$89.0M	Yes
32	Gleevec	Imatinib	-32.1%	$5,302.00	$456.0M	Yes
33	Victoza	Liraglutide	-31.2%	$424.00	$789.0M	Yes
34	Remicade	Infliximab	-28.9%	$2,164.00	$987.0M	Yes
35	Herceptin	Trastuzumab	-28.6%	$3,677.00	$456.0M	Yes
36	Zytiga	Abiraterone	-28.6%	$5,302.00	$456.0M	Yes
37	Fentanyl	Fentanyl Transdermal	-28.6%	$72.00	$178.0M	Yes
38	Vosevi	Sofosbuvir/Velpatasvir/Voxilaprevir	-28.6%	$14,833.00	$178.0M	Yes
39	Venlafaxine	Venlafaxine Hydrochloride	-28.6%	$17.00	$145.0M	Yes
40	Clopidogrel	Clopidogrel Bisulfate	-28.6%	$10.00	$145.0M	Yes
41	Montelukast	Montelukast Sodium	-28.6%	$13.00	$145.0M	Yes
42	Protonix	Pantoprazole (brand)	-28.6%	$58.00	$145.0M	Yes
43	Benicar	Olmesartan	-28.6%	$50.00	$123.0M	Yes
44	Alendronate	Alendronate Sodium	-28.6%	$14.00	$89.0M	Yes
45	Byetta	Exenatide	-28.6%	$359.00	$89.0M	Yes
46	Ibandronate	Ibandronate Sodium	-28.6%	$36.00	$67.0M	Yes
47	Tecfidera	Dimethyl Fumarate	-28.4%	$4,103.00	$1.8B	Yes
48	Saxenda	Liraglutide (weight)	-28.4%	$399.00	$345.0M	Yes
49	Strattera	Atomoxetine	-28.4%	$189.00	$234.0M	Yes
50	Uloric	Febuxostat	-28.4%	$126.00	$234.0M	Yes
51	Losartan	Losartan Potassium	-28.4%	$9.00	$234.0M	Yes
52	Metoprolol	Metoprolol Succinate	-28.4%	$6.00	$178.0M	Yes
53	Actos	Pioglitazone	-28.4%	$30.00	$145.0M	Yes
54	Sertraline	Sertraline Hydrochloride	-28.4%	$10.00	$145.0M	Yes
55	Donepezil	Donepezil Hydrochloride	-28.4%	$17.00	$145.0M	Yes
56	Olanzapine	Olanzapine	-28.4%	$30.00	$145.0M	Yes
57	Risperidone	Risperidone	-28.4%	$22.00	$145.0M	Yes
58	Topiramate	Topiramate	-28.4%	$19.00	$123.0M	Yes
59	Pravastatin	Pravastatin Sodium	-28.4%	$10.00	$89.0M	Yes
60	Levofloxacin	Levofloxacin	-28.4%	$18.00	$89.0M	Yes
61	Zolpidem	Zolpidem Tartrate	-28.4%	$14.00	$89.0M	Yes
62	Pioglitazone	Pioglitazone	-28.4%	$36.00	$89.0M	Yes
63	Citalopram	Citalopram Hydrobromide	-28.4%	$10.00	$67.0M	Yes
64	Levemir	Insulin Detemir	-24.6%	$167.00	$812.0M	Yes
65	Restasis	Cyclosporine (ophthalmic)	-24.6%	$184.00	$456.0M	Yes
66	Pristiq	Desvenlafaxine	-24.6%	$139.00	$345.0M	Yes
67	Complera	Emtricitabine/Rilpivirine/TDF	-24.6%	$4,012.00	$345.0M	Yes
68	Duloxetine	Duloxetine Hydrochloride	-24.6%	$21.00	$234.0M	Yes
69	Levetiracetam	Levetiracetam	-24.6%	$21.00	$178.0M	Yes
70	Oxycodone	Oxycodone Hydrochloride	-24.6%	$27.00	$178.0M	Yes
71	Omeprazole	Omeprazole	-24.6%	$7.00	$123.0M	Yes
72	Carvedilol	Carvedilol	-24.6%	$11.00	$123.0M	Yes
73	Tamsulosin	Tamsulosin Hydrochloride	-24.6%	$8.00	$123.0M	Yes
74	Memantine	Memantine Hydrochloride	-24.6%	$19.00	$123.0M	Yes
75	Fluoxetine	Fluoxetine Hydrochloride	-24.6%	$10.00	$89.0M	Yes
76	Trilipix	Fenofibric Acid	-24.6%	$103.00	$89.0M	Yes
77	Tarceva	Erlotinib	-24.4%	$7,417.00	$178.0M	Yes
78	Ziprasidone	Ziprasidone	-24.4%	$48.00	$89.0M	Yes
79	Galantamine	Galantamine Hydrobromide	-24.4%	$48.00	$89.0M	Yes
80	Humalog	Insulin Lispro	-22.7%	$142.00	$1.6B	Yes
81	Quetiapine	Quetiapine Fumarate	-22.6%	$27.00	$234.0M	Yes
82	Irbesartan	Irbesartan	-22.6%	$18.00	$89.0M	Yes
83	Ropinirole	Ropinirole Hydrochloride	-22.6%	$48.00	$89.0M	Yes
84	Oxcarbazepine	Oxcarbazepine	-22.6%	$48.00	$89.0M	Yes
85	Avastin	Bevacizumab	-22.4%	$3,831.00	$567.0M	Yes
86	Avonex	Interferon Beta-1a	-22.4%	$5,074.00	$345.0M	Yes
87	Velcade	Bortezomib	-22.4%	$5,074.00	$345.0M	Yes
88	Gabapentin	Gabapentin	-22.4%	$12.00	$234.0M	Yes
89	Tracleer	Bosentan	-22.4%	$9,750.00	$234.0M	Yes
90	Intuniv	Guanfacine ER	-22.4%	$144.00	$178.0M	Yes
91	Bupropion	Bupropion Hydrochloride	-22.4%	$12.00	$178.0M	Yes
92	Aggrenox	Aspirin/Dipyridamole	-22.4%	$72.00	$178.0M	Yes
93	Depakote	Divalproex Sodium (brand)	-22.4%	$72.00	$178.0M	Yes
94	Pantoprazole	Pantoprazole Sodium	-22.4%	$10.00	$145.0M	Yes
95	Lamotrigine	Lamotrigine	-22.4%	$17.00	$145.0M	Yes
96	Morphine	Morphine Sulfate	-22.4%	$25.00	$123.0M	Yes
97	Latanoprost	Latanoprost	-22.4%	$25.00	$123.0M	Yes
98	Meloxicam	Meloxicam	-22.4%	$6.00	$89.0M	Yes
99	Ciprofloxacin	Ciprofloxacin	-22.4%	$14.00	$89.0M	Yes
100	Verapamil	Verapamil Hydrochloride	-22.4%	$18.00	$89.0M	Yes

Frequently Asked Questions

Lipitor (Atorvastatin) had a -56.3% year-over-year change, with a current cost of $16.00 per claim.

Drug prices decrease when generic competition enters the market after patent expiration, when biosimilars are approved, through Medicare negotiation (Inflation Reduction Act), or when new competitors launch in the same therapeutic class.

Year-over-year change compares the current average cost per claim to the prior year. Data comes from the CMS Medicare Part D Drug Spending Dashboard, which tracks all drugs covered under Part D plans.