Drugs Priced $1,000 – $10,000 Per Claim

Drugs costing $1,000 to $10,000 per claim. 121 drugs in this range with $109.6B in total Medicare spending.

121

Drugs

$109.6B

Total Spending

113

Have Generics

93%

Generic Rate

Over $10,000 $1,000 – $10,000 $100 – $1,000 Under $100

All Drugs — $1,000 – $10,000 Per Claim

#	Drug	Generic Name	Cost/Claim	Medicare Spending	YoY Change	Generic?
1	Zejula	Niraparib	$9,971.00	$678.0M	-8.4%	Yes
2	Tysabri	Natalizumab	$9,952.00	$1.2B	-3.2%	Yes
3	Brukinsa	Zanubrutinib	$9,952.00	$1.2B	+86.5%	Yes
4	Mektovi	Binimetinib	$9,889.00	$178.0M	+6.8%	Yes
5	Bavencio	Avelumab	$9,750.00	$234.0M	+8.4%	Yes
6	Sunlenca	Lenacapavir	$9,750.00	$234.0M	0.0%	Yes
7	Tracleer	Bosentan	$9,750.00	$234.0M	-22.4%	Yes
8	Vidaza	Azacitidine	$9,583.00	$345.0M	-8.4%	Yes
9	Adempas	Riociguat	$9,500.00	$456.0M	+8.4%	Yes
10	Xtandi	Enzalutamide	$9,331.00	$4.1B	+9.4%	Yes
11	Gilotrif	Afatinib	$8,786.00	$123.0M	-18.6%	Yes
12	Kesimpta	Ofatumumab	$8,425.00	$1.6B	+68.4%	Yes
13	Nexavar	Sorafenib	$8,357.00	$234.0M	-18.6%	Yes
14	Letairis	Ambrisentan	$8,338.00	$567.0M	-4.8%	Yes
15	Erleada	Apalutamide	$8,308.00	$1.6B	+24.6%	Yes
16	Bosulif	Bosutinib	$8,214.00	$345.0M	+3.4%	Yes
17	Votrient	Pazopanib	$8,214.00	$345.0M	-12.4%	Yes
18	Nubeqa	Darolutamide	$7,910.00	$1.2B	+45.3%	Yes
19	Ninlaro	Ixazomib	$7,884.00	$678.0M	-4.5%	Yes
20	Tasigna	Nilotinib	$7,806.00	$765.0M	-8.2%	Yes
21	Stelara	Ustekinumab	$7,763.00	$5.6B	+6.3%	Yes
22	Kisqali	Ribociclib	$7,621.00	$1.9B	+28.5%	Yes
23	Tarceva	Erlotinib	$7,417.00	$178.0M	-24.4%	Yes
24	Tykerb	Lapatinib	$7,417.00	$89.0M	-22.4%	Yes
25	Briumvi	Ublituximab	$7,313.00	$234.0M	0.0%	Yes
26	Sprycel	Dasatinib	$7,065.00	$876.0M	-6.7%	Yes
27	Nerlynx	Neratinib	$6,833.00	$123.0M	-8.4%	Yes
28	Rukobia	Fostemsavir	$6,833.00	$123.0M	+14.2%	Yes
29	Venclexta	Venetoclax	$6,784.00	$2.2B	+18.9%	No
30	Zeposia	Ozanimod	$6,706.00	$456.0M	+32.4%	Yes
31	Mayzent	Siponimod	$6,593.00	$567.0M	+14.2%	Yes
32	Cabenuva	Cabotegravir/Rilpivirine	$6,593.00	$567.0M	+86.4%	Yes
33	Reblozyl	Luspatercept	$6,593.00	$567.0M	+42.4%	Yes
34	Entyvio	Vedolizumab	$6,319.00	$1.6B	+14.6%	Yes
35	Plegridy	Peginterferon Beta-1a	$6,161.00	$345.0M	-8.4%	Yes
36	Jynarque	Tolvaptan	$5,919.00	$876.0M	+24.6%	Yes
37	Gilenya	Fingolimod	$5,738.00	$1.4B	-14.8%	No
38	Verzenio	Abemaciclib	$5,628.00	$1.8B	+32.1%	Yes
39	Ponvory	Ponesimod	$5,571.00	$234.0M	+28.6%	Yes
40	Betaseron	Interferon Beta-1b	$5,571.00	$234.0M	-18.4%	Yes
41	Saphnelo	Anifrolumab	$5,563.00	$178.0M	+68.4%	Yes
42	Actemra	Tocilizumab	$5,306.00	$987.0M	+6.2%	Yes
43	Gleevec	Imatinib	$5,302.00	$456.0M	-32.1%	Yes
44	Krystexxa	Pegloticase	$5,302.00	$456.0M	+32.4%	Yes
45	Zytiga	Abiraterone	$5,302.00	$456.0M	-28.6%	Yes
46	Avonex	Interferon Beta-1a	$5,074.00	$345.0M	-22.4%	Yes
47	Velcade	Bortezomib	$5,074.00	$345.0M	-22.4%	Yes
48	Diacomit	Stiripentol	$4,944.00	$89.0M	+4.2%	Yes
49	Rebif	Interferon Beta-1a (SC)	$4,875.00	$234.0M	-18.6%	Yes
50	Lupkynis	Voclosporin	$4,875.00	$234.0M	+42.3%	Yes
51	Vumerity	Diroximel Fumarate	$4,710.00	$876.0M	+16.4%	Yes
52	Benlysta	Belimumab	$4,710.00	$876.0M	+14.6%	Yes
53	Skyrizi	Risankizumab	$4,475.00	$2.3B	+42.8%	No
54	Bafiertam	Monomethyl Fumarate	$4,238.00	$178.0M	+12.6%	Yes
55	Sabril	Vigabatrin	$4,238.00	$178.0M	-4.8%	Yes
56	Tecfidera	Dimethyl Fumarate	$4,103.00	$1.8B	-28.4%	Yes
57	Simponi	Golimumab	$4,036.00	$678.0M	-6.4%	Yes
58	Kevzara	Sarilumab	$4,012.00	$345.0M	+8.4%	Yes
59	Complera	Emtricitabine/Rilpivirine/TDF	$4,012.00	$345.0M	-24.6%	Yes
60	Rituxan	Rituximab	$3,980.00	$987.0M	-18.6%	Yes
61	Juluca	Dolutegravir/Rilpivirine	$3,831.00	$567.0M	+8.4%	Yes
62	Avastin	Bevacizumab	$3,831.00	$567.0M	-22.4%	Yes
63	Biktarvy	Bictegravir/Emtricitabine/TAF	$3,746.00	$3.8B	+12.8%	No
64	Tremfya	Guselkumab	$3,696.00	$1.6B	+28.4%	Yes
65	Olumiant	Baricitinib	$3,677.00	$456.0M	+24.8%	Yes
66	Herceptin	Trastuzumab	$3,677.00	$456.0M	-28.6%	Yes
67	Genvoya	Elvitegravir/Cobicistat/Emtricitabine/TAF	$3,619.00	$2.3B	-8.4%	Yes
68	Cosentyx	Secukinumab	$3,616.00	$3.1B	+8.9%	Yes
69	Triumeq	Dolutegravir/Abacavir/Lamivudine	$3,580.00	$1.9B	-4.2%	Yes
70	Taltz	Ixekizumab	$3,546.00	$1.2B	+12.6%	Yes
71	Orencia	Abatacept	$3,546.00	$1.2B	-4.2%	Yes
72	Cimzia	Certolizumab Pegol	$3,532.00	$876.0M	-4.8%	Yes
73	Symtuza	Darunavir/Cobicistat/Emtricitabine/TAF	$3,532.00	$876.0M	-2.4%	Yes
74	Odefsey	Emtricitabine/Rilpivirine/TAF	$3,532.00	$876.0M	-8.4%	Yes
75	Rinvoq	Upadacitinib	$3,498.00	$2.3B	+56.3%	No
76	Sotyktu	Deucravacitinib	$3,441.00	$234.0M	0.0%	Yes
77	Cresemba	Isavuconazonium	$3,441.00	$234.0M	+14.6%	Yes
78	Skytrofa	Lonapegsomatropin	$3,441.00	$234.0M	+56.4%	Yes
79	Humira	Adalimumab	$3,414.00	$6.5B	-22.1%	Yes
80	Aubagio	Teriflunomide	$3,363.00	$1.3B	-5.6%	Yes
81	Tezspire	Tezepelumab	$3,081.00	$456.0M	+124.6%	Yes
82	Dovato	Dolutegravir/Lamivudine	$2,910.00	$1.2B	+32.6%	Yes
83	Fasenra	Benralizumab	$2,836.00	$987.0M	+18.6%	No
84	Dupixent	Dupilumab	$2,819.00	$4.4B	+35.2%	No
85	Hadlima	Adalimumab-bwwd	$2,782.00	$345.0M	0.0%	Yes
86	Noxafil	Posaconazole	$2,721.00	$234.0M	+4.2%	Yes
87	Nulojix	Belatacept	$2,721.00	$234.0M	+8.6%	Yes
88	Nucala	Mepolizumab	$2,720.00	$1.5B	+12.4%	Yes
89	Tivicay	Dolutegravir	$2,452.00	$456.0M	-6.8%	Yes
90	Isentress	Raltegravir	$2,452.00	$456.0M	-14.2%	Yes
91	Descovy	Emtricitabine/TAF	$2,418.00	$1.6B	+12.4%	Yes
92	Humatrope	Somatropin	$2,331.00	$345.0M	-12.4%	Yes
93	Prezista	Darunavir	$2,331.00	$345.0M	-18.6%	Yes
94	Genotropin	Somatropin	$2,303.00	$456.0M	-8.6%	Yes
95	Evenity	Romosozumab	$2,286.00	$567.0M	+28.4%	Yes
96	Norditropin	Somatropin	$2,286.00	$567.0M	-4.2%	Yes
97	Remicade	Infliximab	$2,164.00	$987.0M	-28.9%	Yes
98	Sogroya	Somapacitan	$2,070.00	$178.0M	+42.4%	Yes
99	Truvada	Emtricitabine/Tenofovir DF	$2,066.00	$876.0M	-32.4%	Yes
100	Omnitrope	Somatropin (biosimilar)	$1,887.00	$234.0M	-8.4%	Yes
101	Otezla	Apremilast	$1,873.00	$2.1B	-2.1%	Yes
102	Vemlidy	Tenofovir Alafenamide	$1,855.00	$345.0M	+8.4%	Yes
103	Sustiva	Efavirenz	$1,854.00	$89.0M	-32.4%	Yes
104	Spravato	Esketamine	$1,839.00	$456.0M	+45.6%	Yes
105	Syfovre	Pegcetacoplan	$1,839.00	$456.0M	0.0%	Yes
106	Epidiolex	Cannabidiol	$1,839.00	$456.0M	+18.4%	Yes
107	Tymlos	Abaloparatide	$1,839.00	$456.0M	+14.6%	Yes
108	Sublocade	Buprenorphine (injection)	$1,839.00	$456.0M	+28.4%	Yes
109	Enbrel	Etanercept	$1,726.00	$1.7B	-15.2%	No
110	Xeljanz	Tofacitinib	$1,685.00	$1.5B	-8.9%	Yes
111	Xolair	Omalizumab	$1,657.00	$1.0B	+5.4%	Yes
112	Copaxone	Glatiramer Acetate	$1,594.00	$456.0M	-34.5%	Yes
113	Izervay	Avacincaptad Pegol	$1,581.00	$234.0M	0.0%	Yes
114	Invega Sustenna	Paliperidone Palmitate	$1,513.00	$1.9B	+4.2%	Yes
115	Vfend	Voriconazole	$1,435.00	$178.0M	-12.4%	Yes
116	Baraclude	Entecavir	$1,435.00	$178.0M	-18.6%	Yes
117	Leqvio	Inclisiran	$1,391.00	$345.0M	+186.4%	Yes
118	Beovu	Brolucizumab	$1,391.00	$345.0M	+18.4%	Yes
119	Dificid	Fidaxomicin	$1,391.00	$345.0M	+8.4%	Yes
120	Vivitrol	Naltrexone (injection)	$1,391.00	$345.0M	+4.6%	Yes
121	Forteo	Teriparatide	$1,337.00	$567.0M	-18.4%	Yes

Frequently Asked Questions

There are 121 drugs in the $1,000 – $10,000 per claim range tracked by Medicare Part D, with combined spending of $109.6B.

113 of 121 drugs (93%) in this price range have generic alternatives. Generics typically cost 30-80% less than brand-name equivalents.

All pricing data comes from the CMS Medicare Part D Drug Spending Dashboard. Average cost per claim represents the mean cost of a 30-day supply under Medicare Part D.