Drugs Priced $100 – $1,000 Per Claim

Drugs costing $100 to $1,000 per claim. 171 drugs in this range with $131.3B in total Medicare spending.

171

Drugs

$131.3B

Total Spending

160

Have Generics

94%

Generic Rate

Over $10,000 $1,000 – $10,000 $100 – $1,000 Under $100

All Drugs — $100 – $1,000 Per Claim

#	Drug	Generic Name	Cost/Claim	Medicare Spending	YoY Change	Generic?
1	Durysta	Bimatoprost (implant)	$944.00	$234.0M	+28.4%	Yes
2	Vyepti	Eptinezumab	$944.00	$234.0M	+32.4%	Yes
3	Zepbound	Tirzepatide (weight)	$867.00	$1.5B	0.0%	Yes
4	Banzel	Rufinamide	$831.00	$123.0M	-8.4%	Yes
5	Wegovy	Semaglutide (weight)	$820.00	$2.3B	+185.6%	Yes
6	Repatha	Evolocumab	$757.00	$2.6B	+24.6%	No
7	Eylea	Aflibercept	$752.00	$3.7B	-8.3%	Yes
8	Zortress	Everolimus (transplant)	$718.00	$178.0M	+4.2%	Yes
9	Onfi	Clobazam	$718.00	$178.0M	-14.6%	Yes
10	Mircera	Methoxy PEG-Epoetin Beta	$718.00	$178.0M	+4.2%	Yes
11	Adbry	Tralokinumab	$718.00	$178.0M	+42.4%	Yes
12	Myfembree	Relugolix/Estradiol/Norethindrone	$718.00	$178.0M	+32.4%	Yes
13	Praluent	Alirocumab	$706.00	$876.0M	+15.3%	Yes
14	Aimovig	Erenumab	$706.00	$876.0M	+8.4%	Yes
15	Emgality	Galcanezumab	$688.00	$678.0M	+14.8%	Yes
16	Ozempic	Semaglutide	$685.00	$5.0B	+72.5%	No
17	Mounjaro	Tirzepatide	$673.00	$2.5B	+312.4%	No
18	Vabysmo	Faricimab	$663.00	$1.2B	+156.3%	Yes
19	Ajovy	Fremanezumab	$656.00	$567.0M	+12.6%	Yes
20	Lucentis	Ranibizumab	$654.00	$1.1B	-22.3%	Yes
21	Prolia	Denosumab	$632.00	$1.6B	+6.4%	Yes
22	Xcopri	Cenobamate	$553.00	$345.0M	+56.4%	Yes
23	Fycompa	Perampanel	$552.00	$234.0M	+6.8%	Yes
24	Orilissa	Elagolix	$552.00	$234.0M	-4.8%	Yes
25	Qulipta	Atogepant	$528.00	$456.0M	+86.4%	Yes
26	Verquvo	Vericiguat	$511.00	$178.0M	+56.3%	Yes
27	Eliquis	Apixaban	$510.00	$16.6B	+14.2%	Yes
28	Xifaxan	Rifaximin	$498.00	$1.2B	+4.8%	Yes
29	Afrezza	Insulin Human (inhaled)	$496.00	$123.0M	+18.4%	Yes
30	Inbrija	Levodopa (inhaled)	$496.00	$123.0M	+14.6%	Yes
31	Nourianz	Istradefylline	$496.00	$123.0M	+18.6%	Yes
32	Xadago	Safinamide	$496.00	$123.0M	+8.4%	Yes
33	Trulicity	Dulaglutide	$473.00	$4.2B	-4.8%	No
34	Caplyta	Lumateperone	$457.00	$567.0M	+42.3%	Yes
35	Aranesp	Darbepoetin Alfa	$457.00	$567.0M	-4.8%	Yes
36	Rybelsus	Semaglutide (oral)	$428.00	$1.8B	+38.7%	Yes
37	Victoza	Liraglutide	$424.00	$789.0M	-31.2%	Yes
38	Ongentys	Opicapone	$420.00	$178.0M	+28.4%	Yes
39	Saxenda	Liraglutide (weight)	$399.00	$345.0M	-28.4%	Yes
40	Xultophy	Insulin Degludec/Liraglutide	$399.00	$345.0M	+8.4%	Yes
41	Briviact	Brivaracetam	$399.00	$345.0M	+14.6%	Yes
42	Kerendia	Finerenone	$399.00	$345.0M	+124.6%	Yes
43	Epogen	Epoetin Alfa	$399.00	$345.0M	-12.6%	Yes
44	Rexulti	Brexpiprazole	$396.00	$1.2B	+22.4%	Yes
45	Vraylar	Cariprazine	$383.00	$1.7B	+26.3%	No
46	Trelegy Ellipta	Fluticasone/Umeclidinium/Vilanterol	$380.00	$2.9B	+19.8%	No
47	Entresto	Sacubitril/Valsartan	$379.00	$4.8B	+18.3%	No
48	Soliqua	Insulin Glargine/Lixisenatide	$375.00	$234.0M	+4.2%	Yes
49	Corlanor	Ivabradine	$375.00	$234.0M	+4.6%	Yes
50	Lybalvi	Olanzapine/Samidorphan	$375.00	$234.0M	+68.4%	Yes
51	Auvelity	Dextromethorphan/Bupropion	$375.00	$234.0M	0.0%	Yes
52	Aptiom	Eslicarbazepine	$375.00	$234.0M	-4.2%	Yes
53	Parsabiv	Etelcalcetide	$375.00	$234.0M	+6.2%	Yes
54	Neupro	Rotigotine	$375.00	$234.0M	+4.2%	Yes
55	Envarsus XR	Tacrolimus ER	$375.00	$234.0M	+14.2%	Yes
56	Opzelura	Ruxolitinib (topical)	$375.00	$234.0M	+124.6%	Yes
57	Zyvox	Linezolid	$375.00	$234.0M	-18.4%	Yes
58	Rapamune	Sirolimus	$375.00	$234.0M	-8.4%	Yes
59	Procrit	Epoetin Alfa (brand)	$375.00	$234.0M	-18.4%	Yes
60	Byetta	Exenatide	$359.00	$89.0M	-28.6%	Yes
61	Nurtec ODT	Rimegepant	$353.00	$876.0M	+68.4%	Yes
62	Xarelto	Rivaroxaban	$321.00	$5.0B	-1.2%	Yes
63	Breztri Aerosphere	Budesonide/Glycopyrrolate/Formoterol	$305.00	$756.0M	+48.3%	No
64	Ubrelvy	Ubrogepant	$305.00	$567.0M	+32.4%	Yes
65	Latuda	Lurasidone	$300.00	$1.4B	-32.5%	Yes
66	Fanapt	Iloperidone	$290.00	$123.0M	-8.6%	Yes
67	Vtama	Tapinarof	$290.00	$123.0M	0.0%	Yes
68	Auryxia	Ferric Citrate	$285.00	$178.0M	+8.4%	Yes
69	Belbuca	Buprenorphine (buccal)	$285.00	$178.0M	+4.6%	Yes
70	Nexlizet	Bempedoic Acid/Ezetimibe	$285.00	$178.0M	+56.4%	Yes
71	Saphris	Asenapine	$285.00	$178.0M	-18.4%	Yes
72	Azilect	Rasagiline	$285.00	$178.0M	-18.6%	Yes
73	Namzaric	Donepezil/Memantine	$285.00	$178.0M	-14.6%	Yes
74	Eucrisa	Crisaborole	$285.00	$178.0M	-14.2%	Yes
75	Trintellix	Vortioxetine	$278.00	$1.1B	+7.8%	No
76	Lyumjev	Insulin Lispro-aabc	$278.00	$345.0M	+18.6%	Yes
77	Gemtesa	Vibegron	$278.00	$345.0M	+68.4%	Yes
78	Savaysa	Edoxaban	$278.00	$345.0M	+4.6%	Yes
79	Nexletol	Bempedoic Acid	$271.00	$234.0M	+42.3%	Yes
80	Qelbree	Viloxazine	$271.00	$234.0M	+56.4%	Yes
81	Quviviq	Daridorexant	$271.00	$234.0M	+86.4%	Yes
82	Butrans	Buprenorphine (transdermal)	$271.00	$234.0M	-12.4%	Yes
83	Vimpat	Lacosamide	$270.00	$876.0M	+4.2%	Yes
84	Farxiga	Dapagliflozin	$266.00	$3.0B	+31.5%	Yes
85	Tresiba	Insulin Degludec	$262.00	$1.5B	+8.9%	Yes
86	Toujeo	Insulin Glargine U-300	$254.00	$1.2B	-8.4%	Yes
87	Fiasp	Insulin Aspart (fast-acting)	$245.00	$456.0M	+12.3%	Yes
88	Vyvanse	Lisdexamfetamine	$238.00	$1.3B	-18.4%	Yes
89	Rocklatan	Netarsudil/Latanoprost	$232.00	$145.0M	+14.2%	Yes
90	Brilinta	Ticagrelor	$229.00	$567.0M	-8.4%	Yes
91	Vascepa	Icosapent Ethyl	$229.00	$567.0M	-12.4%	Yes
92	Anoro Ellipta	Umeclidinium/Vilanterol	$229.00	$567.0M	+4.2%	Yes
93	Xiidra	Lifitegrast	$229.00	$567.0M	+4.8%	Yes
94	Prograf	Tacrolimus	$229.00	$567.0M	-12.4%	Yes
95	Symbicort	Budesonide/Formoterol	$222.00	$1.9B	-6.4%	Yes
96	Breo Ellipta	Fluticasone/Vilanterol	$221.00	$1.2B	-4.3%	Yes
97	Januvia	Sitagliptin	$219.00	$2.7B	-12.3%	No
98	Jardiance	Empagliflozin	$210.00	$3.9B	+22.7%	Yes
99	Rhopressa	Netarsudil	$206.00	$178.0M	+8.4%	Yes
100	Motegrity	Prucalopride	$206.00	$178.0M	+22.4%	Yes
101	Xtampza ER	Oxycodone ER (abuse-deterrent)	$206.00	$178.0M	-8.4%	Yes
102	Qsymia	Phentermine/Topiramate	$206.00	$178.0M	+8.4%	Yes
103	Reyvow	Lasmiditan	$206.00	$178.0M	+24.6%	Yes
104	Veozah	Fezolinetant	$206.00	$178.0M	0.0%	Yes
105	Mydayis	Mixed Amphetamine Salts ER	$205.00	$345.0M	+12.4%	Yes
106	Vyzulta	Latanoprostene Bunod	$197.00	$123.0M	+12.4%	Yes
107	Kombiglyze	Saxagliptin/Metformin	$197.00	$123.0M	-18.4%	Yes
108	Comtan	Entacapone	$197.00	$123.0M	-14.2%	Yes
109	Contrave	Naltrexone/Bupropion	$189.00	$234.0M	+8.9%	Yes
110	Strattera	Atomoxetine	$189.00	$234.0M	-28.4%	Yes
111	Stiolto Respimat	Tiotropium/Olodaterol	$189.00	$234.0M	-6.8%	Yes
112	Velphoro	Sucroferric Oxyhydroxide	$189.00	$234.0M	+4.6%	Yes
113	Nucynta	Tapentadol	$189.00	$234.0M	-14.6%	Yes
114	Zubsolv	Buprenorphine/Naloxone (SL)	$189.00	$234.0M	-8.6%	Yes
115	Dronedarone	Dronedarone	$189.00	$234.0M	-4.2%	Yes
116	Multaq	Dronedarone HCl	$189.00	$234.0M	-4.6%	Yes
117	Glyxambi	Empagliflozin/Linagliptin	$189.00	$234.0M	+4.6%	Yes
118	Stalevo	Carbidopa/Levodopa/Entacapone	$189.00	$234.0M	-8.4%	Yes
119	Exelon	Rivastigmine (patch)	$189.00	$234.0M	-18.4%	Yes
120	Suboxone	Buprenorphine/Naloxone	$185.00	$1.6B	-12.3%	Yes
121	Dulera	Mometasone/Formoterol	$185.00	$345.0M	-8.4%	Yes
122	Incruse Ellipta	Umeclidinium	$185.00	$345.0M	-2.4%	Yes
123	Dayvigo	Lemborexant	$185.00	$345.0M	+42.6%	Yes
124	OxyContin	Oxycodone ER	$185.00	$345.0M	-32.4%	Yes
125	Restasis	Cyclosporine (ophthalmic)	$184.00	$456.0M	-24.6%	Yes
126	Pradaxa	Dabigatran	$180.00	$876.0M	-9.8%	Yes
127	Janumet	Sitagliptin/Metformin	$180.00	$876.0M	-8.6%	Yes
128	Linzess	Linaclotide	$180.00	$876.0M	+6.4%	Yes
129	Myrbetriq	Mirabegron	$180.00	$876.0M	+6.4%	Yes
130	Synjardy	Empagliflozin/Metformin	$175.00	$567.0M	+14.2%	Yes
131	Levemir	Insulin Detemir	$167.00	$812.0M	-24.6%	Yes
132	Invokana	Canagliflozin	$165.00	$534.0M	-14.7%	Yes
133	Advair Diskus	Fluticasone/Salmeterol	$159.00	$678.0M	-18.9%	Yes
134	Spiriva	Tiotropium	$146.00	$912.0M	-8.9%	Yes
135	Steglatro	Ertugliflozin	$144.00	$178.0M	-12.3%	Yes
136	Livalo	Pitavastatin	$144.00	$178.0M	-8.6%	Yes
137	Intuniv	Guanfacine ER	$144.00	$178.0M	-22.4%	Yes
138	AirDuo RespiClick	Fluticasone/Salmeterol	$144.00	$178.0M	+8.4%	Yes
139	Narcan	Naloxone Nasal Spray	$144.00	$178.0M	+42.4%	Yes
140	Edarbi	Azilsartan	$144.00	$178.0M	-8.4%	Yes
141	Cinacalcet	Cinacalcet	$144.00	$178.0M	-18.6%	Yes
142	Vancomycin	Vancomycin Hydrochloride	$144.00	$178.0M	-4.2%	Yes
143	Jentadueto	Linagliptin/Metformin	$144.00	$178.0M	-4.8%	Yes
144	Lovaza	Omega-3-Acid Ethyl Esters	$143.00	$89.0M	-34.2%	Yes
145	Niaspan	Niacin ER	$143.00	$89.0M	-32.4%	Yes
146	Bijuva	Estradiol/Progesterone	$143.00	$89.0M	+14.2%	Yes
147	Humalog	Insulin Lispro	$142.00	$1.6B	-22.7%	Yes
148	Effient	Prasugrel	$142.00	$123.0M	-18.6%	Yes
149	Savella	Milnacipran	$142.00	$123.0M	-8.4%	Yes
150	Nesina	Alogliptin	$142.00	$123.0M	-14.6%	Yes
151	Welchol	Colesevelam	$142.00	$123.0M	-18.6%	Yes
152	Imvexxy	Estradiol (vaginal insert)	$142.00	$123.0M	+8.4%	Yes
153	NovoLog	Insulin Aspart	$139.00	$1.2B	-19.3%	Yes
154	Semglee	Insulin Glargine-yfgn	$139.00	$345.0M	+42.3%	Yes
155	Pristiq	Desvenlafaxine	$139.00	$345.0M	-24.6%	Yes
156	Focalin XR	Dexmethylphenidate XR	$139.00	$345.0M	-18.6%	Yes
157	Dexilant	Dexlansoprazole	$139.00	$345.0M	-14.2%	Yes
158	Colcrys	Colchicine	$139.00	$345.0M	-14.6%	Yes
159	CellCept	Mycophenolate Mofetil	$139.00	$345.0M	-18.6%	Yes
160	Tacrolimus	Tacrolimus	$139.00	$345.0M	-8.4%	Yes
161	Admelog	Insulin Lispro (biosimilar)	$139.00	$234.0M	-14.2%	Yes
162	Lantus	Insulin Glargine	$136.00	$2.0B	-18.6%	Yes
163	Tradjenta	Linagliptin	$134.00	$567.0M	-4.2%	Yes
164	Concerta	Methylphenidate ER	$131.00	$456.0M	-22.1%	Yes
165	Basaglar	Insulin Glargine (biosimilar)	$130.00	$845.0M	-12.1%	No
166	Onglyza	Saxagliptin	$126.00	$234.0M	-18.4%	Yes
167	Wixela Inhub	Fluticasone/Salmeterol (generic)	$126.00	$234.0M	+18.6%	Yes
168	Tirosint	Levothyroxine (gel cap)	$126.00	$234.0M	+8.6%	Yes
169	Uloric	Febuxostat	$126.00	$234.0M	-28.4%	Yes
170	Adderall XR	Mixed Amphetamine Salts XR	$117.00	$567.0M	-14.2%	Yes
171	Trilipix	Fenofibric Acid	$103.00	$89.0M	-24.6%	Yes

Frequently Asked Questions

There are 171 drugs in the $100 – $1,000 per claim range tracked by Medicare Part D, with combined spending of $131.3B.

160 of 171 drugs (94%) in this price range have generic alternatives. Generics typically cost 30-80% less than brand-name equivalents.

All pricing data comes from the CMS Medicare Part D Drug Spending Dashboard. Average cost per claim represents the mean cost of a 30-day supply under Medicare Part D.